Spindle positioning by membrane adjustment
نویسندگان
چکیده
منابع مشابه
Mechanisms of spindle positioning
Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively. The predominant model for spindle positioning, termed "cortical pulling," involves attachment of the microtubule-based motor cytoplasmic dynein to the cortex, where it exerts a pulling force on microtubules that extend from ...
متن کاملAsymmetric spindle positioning.
When a spindle is positioned asymmetrically in a dividing cell, the resulting daughter cells are unequal in size. Asymmetric spindle positioning is driven by regulated forces that can pull or push a spindle. The physical and molecular mechanisms that can position spindles asymmetrically have been studied in several systems, and some themes have begun to emerge from recent research. Recent work ...
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Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus-end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein-dependent spindle positioning. However, the mechanism of how Spindly regulates spindle positioning has remained elusive. Here, we find that the misalign...
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What mechanisms ensure that temporal and spatial aspects of mitosis are properly coordinated? Part of the answer to this important question emerged from work published recently, which established that a connection between cell cycle progression and the large coiled-coil protein NuMA is key. The mitotic spindle must be positioned accurately during metaphase and anaphase to ensure that the result...
متن کاملSpindle orientation: a question of complex positioning.
The direction in which a cell divides is determined by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. In multiple cell types in multiple animals, spindle orientation is controlled by a conserved biological machi...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2013
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2821